MICROMETRIX S.A. DE C.V.
Pharmaceutical & Nutraceutical Laboratory
Mexican Contract Manufacturer Leader


COMPANY PROFILE

In 1976, an enterprising, visionary man founded Microm�trix, a 100% Mexican company. This project began producing NON PAREIL, a type of microsphere, for Scheramex, now Shering Plough. A few months later, Micrometrix started to develop different techniques for active impregnation and coating of microspheres by time-released capsules, and crystal microcapsulation. The firm simultaneously manufactured capsules, granules, natural and enteric coated pills. A couple of years later, obtained the license for manufacture naturist products such Nopal (prickly pear cactus), garlic, seaweed and alfalfa tablets, among others, as we developed our own natural health branch of the company. We have been diversifying our company according to our customers needs, market research and sanitary authorization in the following fields:

�Biological and Pharmaceutical Laboratory.
�Natural Products Laboratory.
�Herbal Remedy Laboratory.

Micrometrix has grown throughout the years, starting with four persons and today with more than 110 persons involved in the company, at presents sales grows between 30% and 50% annually, except for 1995 (when there was an economic crisis in Mexico) and sales were only 13%, with recovery in 1996 with 20%, the minimum sales increased to date. The best raw materials are employed in our products, made with very high quality and sanity control (cGMP�s) accompanied by biological analysis, environmental studies and various tests for final products.

VISION
Micrometrix S.A. de C.V. conceives of its present projects as the realities of tomorrow. We are determined to play an active role in the global and technological revolution by developing novel natural health products, herbal remedies and raw materials for medicines, by adapting Micrometrix S.A. de C.V. to the daily lives of all human beings everywhere, this recognizing a basic element of our Mission or Institutional Philosophy .

MISSION OR INSTITUTIONAL PHYLOSOPHY
Micrometrix S.A. de C.V. can be defined in seven words: quality, leadership, top management, strategic forecast and timeless. The effort that always has characterized us is the close relationship with our customers and suppliers, with globally oriented behavior inspired by continuous improvement while seeking to eliminate mistakes, which have turned us into pioneers of Mexican products high quality.

OBJECTIVES
Develop a social commitment that contributes to the improvement of the Mexican family, beginning with the families of everybody who works with us each day.
-Extend our line of products according to the market needs.
-Increase commercial, scientific and technological relationships with companies interested in improving the health of human beings and in offering quality products.
-Developing strategic alliances with companies.
-Support the international image of productivity, quality and competitiveness of Mexican products.


SPECIAL TECHNOLOGY
MICROENCAPSULATION & MICROESPHERES

Microencapsulation is a relatively new and rapidly expanding technology. As a process, it is a means of applying relatively thin coatings to small particles of solids or droplets of liquids and dispersions. It has become apparent that the concept offers the industrial pharmacist a new working tool, that provides the means of converting liquids to solids, of altering cololoidal and surface properties, of providing enviromental protection, and of controlling the release characteristics or availability of coated materials. Several of these properties. However the uniqueness of microencapsulation is the smallnes of the coated particles and their subsequent use and adaptation to a wide variety of dosage forms and product applications, that might well included sustained-release or prolonged-action medications, taste.masked tablets, powders and suspensions, single layer tablets containing chemically incompatible ingredients, among others.

The realization of the potential that microencapsulation offers involves a basic understanding of the general properties of microcapsules, such as the the nature of the core and coating materials, the stabiility and release characteristics, specially the method employed in the manufacture may well result in products of varied composition, quality and utility. There are three important areas of current microencapsulation: the stabilization of core materials, the control of release or availability of core materials and separation of chemically reactive ingredients. In thissense the release properties of microencapsulated materials require detailed consideration as the coated material must be release in a predictable and reproducible manner. The rate of release is a function of the permeability of the coating to the extraction fluid, the permselectivity of the coating to core material, the coating thickness, and the concentration gradient existing across the coating membrane. Prolonged action or sustained- release formulations are obviously the most important qualities of the best components? absorption.

TIME RELEASE MICROESPHERES DEVELOPED BY US:

Pseudoephedrine,hydrochloride Naftidrofuryl
Chlorpheniramine, Maleate Metoclopramide
Carbinoxamine, Maleate Connarizine
Vitamins Minerals
Furosemide Citric acid
Vincamine Nifedipine
Teophilline Ascorbic acid
Fenformin Diclofenacum sodic
Acetylsalicylic acid Bicarbonate of calcium

THESE OR OTHER ACTIVE PRODUCTS CAN BE DELIVERED IN THE FOLLOWING PRESENTATIONS:
1.- Microespheres in bulk at the required concentration and release profile.
2.- Filled already in capsules at the desire dosage size or specification mentioned above.
3.- Finished product in final presentation that the client may require*


SOME OF OUR CLIENTS

PHARMACEUTICAL FIELD

Amstrong Aventis Pharma Brystol Myers Squibb
ByK Gulden Carnot Columbia
Eli Lilly y Cia. Italmex Janssen
Laboratorios Romer Medix Novag infancia
Pfizer Productos Cientificos Quimica Knoll
Romacel Sanofi Sinthelabo Serral

NUTRACEUTICAL FIELD

California Fitness (Hungary & Canada) Carrare Laboratoires (France) Comida Med (Germany)
Farmacia Paris (Mexico) Genesis Research (USA) House of Fuller (Mexico)
Matsushin (Japan) Mitsuba (Japan) Neways (Mexico)
Nutrisa (Mexico) Shaklee (Mexico) Pronat (Mexico)


OUR PRODUCTS IN THE NUTRACEUTICAL FIELD

NOPAL PLUS: According with several researches realized by Mexican authorities, we can affirm that has been consumed in mesoamerica since more than 600 years, emphasizing its nutritional, botanical, ecological and culinary properties. The most reliable properties of Nopal (prickly pear) are the sugar reduction in the blood, by consequence reduce triglirecidus and cholesterol, is an effective supplement in weight control, which additionally provides proteins, minerals and natural fiber. We make the dehydration process, guarantee high quality of final product.

SHIITAKE PLUS:The shiitake is a Japanese mushroom (Lentinus edodes) with extraordinary properties. We strive through the processes of cultivation, dehydration, grinding and sanitation to improve the high quality of this product. The shiitake with its different nutrients and a unique combination of components, affords the following benefits:
- Increase of the general vitality of human organism.
- Diminishing of the unhealthy effects of fatty food.
- Antiviral properties.
- Action against chronic fatigue.
- Helps against hypertension.

MASTICAL-D: Chewable calcium tablets with an excellent chocolate flavor, added with vitamin A and D3 to complement your body needs. One tablets provides 600 mg. of Calcium Ion, and the vitamins used in it�s exclusive formula helps to total the body absorption.

BIOALFA: An extraordinary easy-to-digest mixture of alfalfa (Lucerne) and parsley, that provides vitamins A and C, calcium, phosphorus, proteins and natural fiber, a nutritional complement that provides extra energy to the organism.

SPIRALGA: This product contains 100% of dehydrated spirulina seaweed, one of the highest protein nutrients (nearly 70%) that contains no fat. Spirulina seaweed was the sacred food of the Aztecs and is the spatial food of future. It is the most complete nourishment and has contains all the nutrients needing by the body, including:
-Beta carotenum: 25 times more than carrots.
-B12 vitamins: 4 times more than beef liver.
-E vitamin: 3 times more than wheat germ.
-Calcium: 5 times more than milk.
-Protein: 3 times more than fish, chicken, or beef.
-Amino acids: nearly all of these.
-Antioxidizer: A wide spectrum of natural antioxidants.

AJO PLUS: The garlic-like supplement has diverse uses in international food because of its several health properties. The sugar-coated pill is gastric-resistant, implying that it does not experience any alteration in the stomach and that it dissolves in the intestine, avoiding characteristic garlic breath. The principal benefits of this product are:
-Increase the blood circulation.
-Is rich in potassium.
-Acts against the cholesterol in blood.
-Provides a better quality of life for sufferers of arthritis, varicose veins and rheumatism.

MICROLIBER: A sugar-coated pill of dehydrated beef has the very highest of protein contents, and which is also sanitized to provide a high quality product for export. This product is recommended to every family member, especially athletes with unusual physical demands, body builders, and individuals with marginal nourishment and anemia. We dehydrate the product and guarantee its selection, purity and hygiene.

SEN PLUS: The properties of this extraordinary mixture of medicinal plants provides an excellent 100% natural laxative, perfectly sanitized. This product contributes to weight control and reduction, without affecting the organism. The exclusive formula additionally improves digestion and ideal for constipation and weight problems. This product does not cause addiction nor does it contain noxious ingredients.

LEVADURA PLUS: A natural product with generous supply of proteins, amino acids and vitamins, especially vitamin B complex. Levadura Plus is also an excellent product that reconstitutes intestinal flora.
-Contains vitamin B complex for improvement of the central nervous and respiratory systems.
-Provides important benefits for all individuals, especially including athletes and sufferers of anemia.

MICROPAC: Compressible sugar is an excellent excipient to be used in the manufacturing process of chewing and conventional tablets by direct compress method. It?s sweeten colorant, diluent and cohesioner with low humidity, excellent fluidity and stability.


SAN LORENZO #97, COL. PARAJE SAN JUAN IZTAPALAPA
C.P. 09830, MEXICO CITY TEL. +52(55)5612-0163 FAX. +52(55)5612-8979

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